上海海洋大学深渊科学技术研究中心

  深渊科学技术项目的灵感来自于“蛟龙号”。“蛟龙号”在5000米级海试和7000米级海试过程中邀请海洋科学家参与海试过程,充分挖掘了每个试验潜次的科学价值,让参试的工程技术人员体会到了科学家与工程技术人员密切结合的好处。另一方面,从2010年美国纪念人类到达马里亚纳海沟的最深处---“挑战者深渊”50周年的纪念专刊中了解到了深渊科学与技术是海洋领域最前沿的科学与技术。因此,在“蛟龙号”7000米级海试结束后,具有国际视野的海洋地质学家、也是助蛟龙号项目成功的幕后英雄、“蛟龙号”海试技术咨询专家组组长、海试现场验收组长、美国明尼苏达大学高级科学家丁抗博士给科技部提出了如下的建议:“对比目前国际上能携带科学家的载人潜水器,唯有蛟龙号能够在属于所谓HadalDepth(海斗深度,指6000-11000米的深度区间)的 6500-7100米深度段进行科研作业,而这样的深度具有极为特殊的生物活动,但是我国科技界拥有的这个独一无二的深潜优势估计将在3-5年或者更短的时间内丧失;这次的海底作业表明,蛟龙号7000米海试的下潜区域是一个具有重要科学研究意义的地点,它紧挨挑战者深渊,具有丰富和明显的生物与地质活动的多样性,并且能够得到所属国密克罗尼西亚政府的支持。 查看详情>>

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深渊科学团队

陈良标

岗位: 深渊中心科学团队成员
职称: 教授,博士生导师
研究领域: 鱼类比较基因组学,生物信息和干细胞生物学
博士,研究员,教授,博士生导师。2013年1月起, 任上海海洋大学二级教授,水产资源开发和利用教育部重点实验室主任。
1984-1988杭州大学生物系细胞生物学专业, 学士学位。
1988-1991中国科学院发育生物学研究所, 硕士学位。
1991-1996美国University of Illinois at Urbana-Champaign, 分子生理学博士学位。
1997-1999美国National Institutes of Health, 博士后。
2000-2001美国生物信息公司Doubletwist Inc.,数据库工程师。
2001-2002浙江大学生命科学院,教授。
2003-2012,中科院遗传发育所,研究员。
2004年入选中科院"百人计划"。
2006年获国家杰出青年基金.
2013年-至今,上海海洋大学生命科学院教授.

主要研究方向是鱼类比较基因组学,生物信息和干细胞生物学。在抗冻基因的起源和抗寒的分子机制,基因组进化和干细胞表面分子特征等方面取得了重要成果。在Nature,PNAS,Molecular Biology and Evolution, Bioinformatics等领域主流杂志发表了一系列高影响力论文。

主持的主要项目:
1.国家自然科学基金重点,南极鱼类的功能基因组学研究, 2003-2008,125 万元;
2.973课题,鱼类抗逆基因的克隆和抗逆机理研究, 2004-2009,140万;
3.863课题,跨物中转录组比较平台的构建,2006-2008,90万元;
4.基金委面上,III型抗冻蛋白的进化研究, 2005-2009, 27万;
5.国家杰出青年基金,小分子RNA的进化研究,2007-2010,200万元;
6.基金委重大国际合作,极端环境下蛋白质组的进化,2009-2013,110万元;
7.转基因重大专项,抗寒基因的克隆和国内研究新技术的研究,2010-2012,300万;
8.基金委面上,肿瘤干细胞的小分子RNA功能和网络研究,2010-2012, 32万;
9.973课题, 鱼类抗寒分子育种的基础研究, 2010-2014,270万元。


主要论文:

1.Qianghua Xu, Guang Li, Lixue Cao, Zhongjun Wang, Hua Ye, Xiaoyin Chen, Xi Yang, Yiquan Wang, Liangbiao Chen*. (2012). Proteomic characterization and evolutionary analyses of zona pellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostoma belcheri. BMC Evolutionary Biology. In press
2.Gu Bin, Zhang Jiarong, Wang Shihao, Song Xiuli, Xu Cheng, Chen Liangbiao*, Zhang Ming* (2012). Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells and Development. 21: 2878-90.
3.Yang R, Dai Z, Chen S, Chen L*.(2011). MicroRNA-mediated gene regulation plays a minor role in the transcriptomic plasticity of cold-acclimated zebrafish brain tissue. BMC Genomics. 12:605.
4.Gu B, Zhang J, Wu Y, Zhang X, Tan Z, Lin Y, Huang X, Chen L, Yao K, Zhang M. (2011). Proteomic analyses reveal common promiscuous patterns of cell surface proteins on human embryonic stem cells and sperms. PLoS One. 6(5):e19386.
5.Wu R, Gu B, Zhao X, Tan Z, Chen L, Zhu J, Zhang M. (2011). Derivation of multipotent nestin(+)/CD271 (-)/STRO-1 (-) mesenchymal-like precursors from human embryonic stem cells in chemically defined conditions. Hum Cell. 2011 Jun 15. [Epub ahead of print]
6.Lu Y, Su Z, Li Y, Luo J, Tan Z, Ji H, Zhu W, Yu G, Chen L, Zhang M. (2011). Generation and characterisation of rabbit monoclonal antibodies against the native cell surface antigens of embryonic stem cells. J Genet Genomics. 37(7):483-92.
7.Tan Z, Zhang J, Su Z, Gu B, Jiang X, Luo J, Ji H, Wang G, Tao B, Zhao X, Chen L, Yu G, Zhu W, Zhang M. (2011). Production of rabbit monoclonal antibodies against mouse embryonic stem cells and identification of pluripotency-associated surface antigens. J Immunol Methods. 365(1-2):149-57.
8.Deng C, Cheng CH, Ye H, He X, Chen L*. (2010). Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc Natl. Acad. Sci. U S A. 107(50):21593-8.
9.Gu B, Zhang J, Wang W, Mo L, Zhou Y, Chen L, Liu Y, Zhang M. (2010). Global expression of cell surface proteins in embryonic stem cells. PLoS One. 5(12):e15795.
10.Wu R, Xu C, Jin F, Tan Z, Gu B, Chen L, Yao X, Zhang M. (2010). Derivation, characterization and differentiation of a new human embryonic stem cell line from a Chinese hatched blastocyst assisted by a non-contact laser system. Hum Cell. 23(3):89-102.
11.Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. (2010). Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Biochem Biophys Res Commun.394(2):418-23.
12.Su Z, Wu R, Tan Z, Li Y, Chen L, Luo J, Zhang M.(2010). Early homing behavior of Stro-1- mesenchyme-like cells derived from human embryonic stem cells in an immunocompetent xenogeneic animal model. Biochem Biophys Res Commun. 394(3):616-22.
13.Dai Z., Chen Z., Hua Y., Wang Y., Peng S. and Chen L*. (2009). Characterization of microRNAs in cephalochordates reveals a correlation between miRNA repertoire homology and morphological similarity in chordate evolution. Evolution and Development. 11(1) 41-49.
14.Xie C., Huang H., Wei S., Song L., Zhang J., Ritchie R., Chen L., Zhang M. and Chen Y.(2009). A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem Cells. Stem cells and Development. 18:741-8.
15.Chen Z, Cheng CH, Zhang J, Cao L, Chen L, Zhou L, Jin Y, Ye H, Deng C, Dai Z, Xu Q, Hu P, Sun S, Shen Y, and Chen L*. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949. (论文获得了J. of Exp. Biol. 和Faculty 1000的专文评论)。
16.Zhang J, Dend C, Wang J. and Chen L*. (2008). Characterization of a two-domain antifreeze protein gene in Antarctic eelpout Lycodichthyus dearborni. Polar Biol. DOI 10.1007/s00300-008-0499-8.
17.Xu Q, Cheng CH, Hu P, Ye H, Chen Z, Cao L, Chen L, Shen Y, Chen L*. (2008). Adaptive evolution of hepcidin genes in antarctic notothenioid fishes. Mol. Biol. Evol. 25(6):1099-112.
18.Zuozhou Chen, Weilin Wang, Xuefeng Bruce Ling, Jane Jijun Liu and Liangbiao Chen* (2006). GO-Diff: Mining functional differentiation between EST-based transcriptomes. BMC Bioinformatics 2006, 7:72
19.Lei Chen, Lixue Cao, Longhai Zhou, Yudong Jing, Zuozhou Chen,Cheng Deng, Yu Shen, Liangbiao Chen*. Trehalose as a good candidate for enriching full-length cDNAs in cDNA library construction. Journal of Biotechnology. 2007, 127: 402–407
20.Huarong Huang, Xiaoli Zhao, Liangbiao Chen, Chao Xu, Xing Yao, Yongliang Lu, Licheng Dai, Ming Zhang. Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochemical and Biophysical Research Communications. 2006, 351: 321-327
21.Jane Jijun Liu, Gene Cutler, Wuxiong Li, Zheng Pan, Sihua Peng,Tim Hoey, Liangbiao Chen and Xuefeng Bruce Ling (2005) Multiclass cancer classification and biomarker discovery using GA-based algorithms. Bioinformatics 21: 2691-7
22.Zuozhou Chen, Chenghai Xue, Sheng Zhu, Fengfeng Zhou, Xuefeng Bruce Ling, Guoping Liu, Liangbiao Chen* (2005). GoPipe: Streamlined Gene Ontology Annotation for Batch Anonymous Sequences with Statistics. Prog. Biochem. Biophys. 32(2): 187-191.
23.Sihua Peng, Qianghua Xu, Xuefeng Bruce Ling, Xiaoning Peng, Wei Du, Liangbiao Chen* (2003). Molecular classification of cancer types from microarray data using the combination of Genetic Algorithms and Support Vector Machines. FEBS Letters, 555:358-62.
24.Shuyu Li, Gene Cutler, Jane Jijun Liu, Timothy Hoey, Liangbiao Chen, Peter G. Schultz, Jiayu Liao, Xuefeng Bruce Ling (2003). A Comparative Analysis Of HGSC and Celera Human Genome Assemblies and Gene Sets. Bioinformatics, 19(13):1597-605.
25.Chi-Hing C. Cheng, Liangbiao Chen, Thomas Near, Yumi Jin, (2003). Functional antifreeze glycoprotein genes in temperate-water New Zealand nototheniid fish infer an Antarctic origin. Mol. Biol. Evol. 20(11):1897-908.
26.Chi-Hing C. Cheng and Liangbiao Chen. Evolution of Antifreeze Glycoprotein. Nature. 1999, 401:443-444.
27.Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. USA. 1997, 94:3811-3816. (论文获得了Nature,Science News, PNAS的专文评论,并收入进化领域的多种教科书)。
28.Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod. Proc. Natl. Acad. Sci. USA. 1997, 94:3817-3822.
29.SH Hahm, Liangbiao Chen, C Patel, J Erickson, TI Bonner, Eberhard Weihe, K. –H. Schafer, Lee E. Eiden. Upstream sequencing and functional characterization of the human cholinergic gene locus. Journal of Molecular Neuroscience. 1998, 9(3): 223-236.
30.Berkhard Schutz, Liangbiao Chen, K. –H. Schafer, Eberhard Weihe, Lee E. Eiden. Somatomotor neuron-specific expression of the cholinergic gene locus in transgenic mice. Neuroscience. 2000, 96(4): 707-722